• Anatomical variations in the circle of Willis are associated with increased odds of intracranial aneurysms: The Tromsø study 

      Hindenes, Lars Bakke; Ingebrigtsen, Tor; Isaksen, Jørgen Gjernes; Håberg, Asta; Johnsen, Liv-Hege; Herder, Marit; Mathiesen, Ellisiv B.; Vangberg, Torgil Riise (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-07-25)
      Purpose: Studies on patients suggest an association between anatomical variations in the Circle of Willis (CoW) and intracranial aneurysms (IA), but it is unclear whether this association is present in the general population. In this cross-sectional population study, we investigated the associations between CoW anatomical variations and IA.<p> <p>Methods: We included 1667 participants from a ...
    • Circle of Willis variants and cerebrovascular health: Representations, prevalences, functions and related consequences. Incomplete anatomy and changes to flow appear to induce more unfavourable health outcomes 

      Hindenes, Lars Bakke (Doctoral thesis; Doktorgradsavhandling, 2021-12-03)
      <p><i>Background:</i> The Circle of Willis (CoW) is a circular structure of arteries in which most of the blood flowing to our brains pass through. The structure has primarily been regarded as important for its ability to redistribute blood flow in case of acute arterial occlusion, but may also have a role in dampening the pressure gradient in cerebral blood flow. The CoW anatomy also varies ...
    • An incomplete Circle of Willis is not a risk factor for white matter hyperintensities: The Tromsø Study 

      Hindenes, Lars Bakke; Håberg, Asta Kristine; Mathiesen, Ellisiv B; Vangberg, Torgil Riise (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-12-11)
      <p><i>Objective - </i>The Circle of Willis (CoW) is often underdeveloped or incomplete, leading to suboptimal blood supply to the brain. As hypoperfusion is thought to play a role in the aetiology of white matter hyperintensities (WMH), the objective of this study was to assess whether incomplete CoW variants were associated with increased WMH volumes compared to the complete CoW. <p><i>Methods - ...
    • Modelling and analysis of health care services using regression and Markov models 

      Hindenes, Lars Bakke (Master thesis; Mastergradsoppgave, 2017-05-12)
      Using data from electronic health records this thesis aims to model and analyse health care services provided to adult patients with chronic conditions. Two aspects of health care services, with unique aims, have been examined. The first aspect is related to the aim of investigating factors affecting the patients' self experienced quality of the health care encounters with regards to satisfaction, ...
    • Variations in the Circle of Willis in a large population sample using 3D TOF angiography: The Tromsø Study 

      Hindenes, Lars Bakke; Håberg, Asta; Johnsen, Liv-Hege; Mathiesen, Ellisiv B.; David, Robben; Vangberg, Torgil Riise (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-11-03)
      The main arteries that supply blood to the brain originate from the Circle of Willis (CoW). The CoW exhibits considerable anatomical variations which may have clinical importance, but the variability is insufficiently characterised in the general population. We assessed the anatomical variability of CoW variants in a community-dwelling sample (N = 1,864, 874 men, mean age = 65.4, range 40–87 years), ...